Overview
GABA works by blocking brain signals (neurotransmissions). There is interest in using GABA as a dietary supplement. But when taken by mouth, GABA may not be able to cross the blood-brain barrier. Therefore it is unknown if GABA supplements have effects on the brain.
People use GABA for many different conditions, including stress, anxiety, depression, and high blood pressure, but there is no good scientific evidence to support its use.
Uses & Effectiveness ?
We currently have no information for GAMMA-AMINOBUTYRIC ACID (GABA) overview.
Side Effects
When placed under the tongue: There isn't enough reliable information to know if GABA is safe or what the side effects might be.
Special Precautions and Warnings
Interactions ?
Medications for high blood pressure (Antihypertensive drugs) interacts with GAMMA-AMINOBUTYRIC ACID (GABA)
GABA might lower blood pressure. Taking GABA along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
Moderate Interaction
Be cautious with this combination
Dosing
Abe, Y., Umemura, S., Sugimoto, K., Hirawa, N., Kato, Y., Yokoyama, N., Yokoyama, T., Iwai, J., and Ishii, M. Effect of green tea rich in gamma-aminobutyric acid on blood pressure of Dahl salt-sensitive rats. Am.J.Hypertens. 1995;8(1):74-79. View abstract.
Akama, K., Kanetou, J., Shimosaki, S., Kawakami, K., Tsuchikura, S., and Takaiwa, F. Seed-specific expression of truncated OsGAD2 produces GABA-enriched rice grains that influence a decrease in blood pressure in spontaneously hypertensive rats. Transgenic Res. 2009;18(6):865-876. View abstract.
Baldrighi, G. and Tronconi, L. [Research on the antihypertensive effect induced by the mebutamate-GABA (gamma-aminobutyric acid) combination in essential hypertension]. Clin.Ter. 5-15-1966;37(3):207-234. View abstract.
Belloni, L. and Savioli, F. [Experience in hypotensive treatment with the association of mebutamate and gamma-aminobutyric acid]. Minerva Med. 2-17-1967;58(14):501-509. View abstract.
Belloni, L., Savioli, F., and Barbieri, C. [On the antihypertensive properties of gamma-aminobutyric acid. Clinical experience in 29 hypertensive patients]. Arch.Maragliano.Patol.Clin. 1966;22(1):119-145. View abstract.
Benassi, E., Besio, G., Cupello, A., Mainardi, P., Patrone, A., Rapallino, M. V., Vignolo, L., and Loeb, C. W. Evaluation of the mechanisms by which gamma-amino-butyric acid in association with phosphatidylserine exerts an antiepileptic effect in the rat. Neurochem.Res. 1992;17(12):1229-1233. View abstract.
Cavagnini, F., Benetti, G., Invitti, C., Ramella, G., Pinto, M., Lazza, M., Dubini, A., Marelli, A., and Muller, E. E. Effect of gamma-aminobutyric acid on growth hormone and prolactin secretion in man: influence of pimozide and domperidone. J.Clin.Endocrinol.Metab 1980;51(4):789-792. View abstract.
Cho, Y. R., Chang, J. Y., and Chang, H. C. Production of gamma-aminobutyric acid (GABA) by Lactobacillus buchneri isolated from kimchi and its neuroprotective effect on neuronal cells. J.Microbiol.Biotechnol. 2007;17(1):104-109. View abstract.
Danilova, I. N., Neretin, V. I., and Nesterova, L. A. [Effect of aminalon electrophoresis on brain bioelectrical activity in cerebral atherosclerosis patients with disordered cerebral blood circulation]. Vopr.Kurortol.Fizioter.Lech.Fiz Kult. 1980;(4):13-17. View abstract.
ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406. View abstract.
Enna, S. J. GABA. San Diego: Academic Press/Elsevier;2006.
Furukawa, T. and Kushiku, K. Antagonism by gamma-aminobutyric acid of the stimulant effect of angiotensin II on cardiac sympathetic ganglia in spinal dogs. Naunyn Schmiedebergs Arch.Pharmacol. 1981;317(2):149-153. View abstract.
Garkusha, L. G., Kukhtevich, I. I., and Proskurkina, O. A. [Treatment of chronic diffuse arachnoiditis with aminalon]. Vrach.Delo 1978;(1):114-116. View abstract.
Glebova, O. S. [Peculiarities of neuro-psychological and autonomic disorders in patients with remote consequences of closed craniocerebral injury]. Lik.Sprava. 2007;(5-6):85-89. View abstract.
Hayakawa, K., Kimura, M., Kasaha, K., Matsumoto, K., Sansawa, H., and Yamori, Y. Effect of a gamma-aminobutyric acid-enriched dairy product on the blood pressure of spontaneously hypertensive and normotensive Wistar-Kyoto rats. Br.J.Nutr. 2004;92(3):411-417. View abstract.
Jones, E. A., Schafer, D. F., Ferenci, P., and Pappas, S. C. The GABA hypothesis of the pathogenesis of hepatic encephalopathy: current status. Yale J.Biol.Med. 1984;57(3):301-316. View abstract.
Kawabata, K., Tanaka, T., Murakami, T., Okada, T., Murai, H., Yamamoto, T., Hara, A., Shimizu, M., Yamada, Y., Matsunaga, K., Kuno, T., Yoshimi, N., Sugie, S., and Mori, H. Dietary prevention of azoxymethane-induced colon carcinogenesis with rice-germ in F344 rats. Carcinogenesis 1999;20(11):2109-2115. View abstract.
Kim, J. Y., Lee, M. Y., Ji, G. E., Lee, Y. S., and Hwang, K. T. Production of gamma-aminobutyric acid in black raspberry juice during fermentation by Lactobacillus brevis GABA100. Int.J.Food Microbiol. 3-15-2009;130(1):12-16. View abstract.
Likhodeev, V. A., Spasov, A. A., Isupov, I. B., and Mandrikov, V. B. [Effects of aminalon, fenibut, and picamilon on the typological parameters of cerebral hemodynamics in swimmers with dysadaptation syndrome]. Eksp.Klin.Farmakol. 2009;72(4):15-19. View abstract.
Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):440-446. View abstract.
Lu, J. and Greco, M. A. Sleep circuitry and the hypnotic mechanism of GABAA drugs. J.Clin.Sleep Med. 4-15-2006;2(2):S19-S26. View abstract.
Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. View abstract.
Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448. View abstract.
Mori, H., Kawabata, K., Yoshimi, N., Tanaka, T., Murakami, T., Okada, T., and Murai, H. Chemopreventive effects of ferulic acid on oral and rice germ on large bowel carcinogenesis. Anticancer Res. 1999;19(5A):3775-3778. View abstract.
Nakamura, H., Takishima, T., Kometani, T., and Yokogoshi, H. Psychological stress-reducing effect of chocolate enriched with gamma-aminobutyric acid (GABA) in humans: assessment of stress using heart rate variability and salivary chromogranin A. Int J Food Sci Nutr 2009;60 Suppl 5:106-113. View abstract.
Ouyang, C., Guo, L., Lu, Q., Xu, X., and Wang, H. Enhanced activity of GABA receptors inhibits glutamate release induced by focal cerebral ischemia in rat striatum. Neurosci.Lett. 6-13-2007;420(2):174-178. View abstract.
Park, K. B. and Oh, S. H. Cloning, sequencing and expression of a novel glutamate decarboxylase gene from a newly isolated lactic acid bacterium, Lactobacillus brevis OPK-3. Bioresour.Technol. 2007;98(2):312-319. View abstract.
Poemnyi, F. A. and Trubnikov, B. M. [Treatment of infectious-toxic and traumatic lesion, of the hypothalamic region with aminalon and gammalon]. Klin.Med.(Mosk) 1975;53(9):52-55. View abstract.
Powers, M. E., Yarrow, J. F., McCoy, S. C., and Borst, S. E. Growth hormone isoform responses to GABA ingestion at rest and after exercise. Med.Sci.Sports Exerc. 2008;40(1):104-110. View abstract.
Shizuka, F., Kido, Y., Nakazawa, T., Kitajima, H., Aizawa, C., Kayamura, H., and Ichijo, N. Antihypertensive effect of gamma-amino butyric acid enriched soy products in spontaneously hypertensive rats. Biofactors 2004;22(1-4):165-167. View abstract.
Smirnov, A. N. [Cardiovascular preparations; clofibrate and aminalon]. Feldsher.Akush. 1978;43(3):37-38. View abstract.
Tillakaratne, N. J., Medina-Kauwe, L., and Gibson, K. M. gamma-Aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues. Comp Biochem.Physiol A Physiol 1995;112(2):247-263. View abstract.
Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794. View abstract.
Yamakoshi, J., Fukuda, S., Satoh, T., Tsuji, R., Saito, M., Obata, A., Matsuyama, A., Kikuchi, M., and Kawasaki, T. Antihypertensive and natriuretic effects of less-sodium soy sauce containing gamma-aminobutyric acid in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 2007;71(1):165-173. View abstract.
Yoshimura, M., Toyoshi, T., Sano, A., Izumi, T., Fujii, T., Konishi, C., Inai, S., Matsukura, C., Fukuda, N., Ezura, H., and Obata, A. Antihypertensive effect of a gamma-aminobutyric acid rich tomato cultivar 'DG03-9' in spontaneously hypertensive rats. J.Agric.Food Chem. 1-13-2010;58(1):615-619. View abstract.
Abdou AM, Higashiguchi S, Horie K, et al. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. Biofactors 2006;26:201-8. View abstract.
Bloom FE, Kupfer DJ. Psychopharmacology: The Fourth Generation of Progress. New York, NY: Raven Press, Ltd., 1995.
Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015.
Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54. View abstract.
Cavagnini F, Pinto M, Dubini A, et al. Effects of gamma aminobutyric acid (GABA) and muscimol on endocrine pancreatic function in man. Metabolism 1982;31:73-7. View abstract.
Cocito L, Bianchetti A, Bossi L, et al. GABA and phosphatidylserine in human photosensitivity: a pilot study. Epilepsy Res 1994;17:49-53. View abstract.
Franco L, Sánchez C, Bravo R, Rodríguez AB, Barriga C, Romero E, Cubero J. The sedative effect of non-alcoholic beer in healthy female nurses. PLoS One. 2012;7(7):e37290. doi: 10.1371/journal.pone.0037290. Epub 2012 Jul 18. View abstract.
Gamma-aminobutyric acid (GABA), Monograph. Altern.Med.Rev. 2007;12:274-79. View abstract.
Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7. View abstract.
Hashimoto M, Yokota A, Matsuoka S, et al. [Choreo-ballistic status treated by GABA]. No To Hattatsu 1989;21:481-85. View abstract.
Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95. View abstract.
Ivanova, RI and Senenkova, SI. [Experience with the use of aminalon in the complex treatment of children with meningococcal infections]. Zh.Nevropatol.Psikhiatr.Im S.S.Korsakova 1981;81(10):1502-1504. View abstract.
Kalant H, Roschlau WHE, Eds. Principles of Med. Pharmacology. New York, NY: Oxford Univ Press, 1998.
Lapaev EV, Voinova II, Vorob'ev OA, et al. [Aminalon as an agent for the prevention of motion sickness]. Zh.Ushn.Nos.Gorl.Bolezn. 1978;(5):35-9. View abstract.
Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . View abstract.
Lupandin VM, Lando LI, Gromova EA, et al. [Role of biogenic amines in the pathogenesis of intellectual disorders in children with minimal psychoorganic syndromes]. Zh.Nevropatol.Psikhiatr.Im S.S.Korsakova 1978;78:1538-44. View abstract.
Mishunina TM, Kononenko VI, Komissarenko IV, et al. [The effect of GABA-ergic preparations on the function of the hypothalamo-hypophyseal-adrenal system in patients with Itsenko-Cushing disease]. Probl.Endokrinol.(Mosk) 1991;37:28-31. View abstract.
Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. View abstract.
Shimada M, Hasegawa T, Nishimura C, et al. Anti-hypertensive effect of gamma-aminobutyric acid (GABA)-rich Chlorella on high-normal blood pressure and borderline hypertension in placebo-controlled double blind study. Clin.Exp.Hypertens. 2009;31:342-54. View abstract.
Shoulson I, Kartzinel R, and Chase TN. Huntington's disease: treatment with dipropylacetic acid and gamma-aminobutyric acid. Neurology 1976;26:61-3. View abstract.
Sil'vestrov VP, Kinitin AV, and Chesnokova, IV. [Immunological and metabolic disorders and the means for their correction in patients with chronic bronchitis]. Ter.Arkh. 1991;63:7-11. View abstract.
Wu SJ, Chang CY, Lai YT, Shyu YT. Increasing ?-aminobutyric acid content in vegetable soybeans via high-pressure processing and efficacy of their antidepressant-like activity in mice. Foods. 2020;9(11):1673. View abstract.
Wu Z, Wang P, Pan D, Zeng X, Guo Y, Zhao G. Effect of adzuki bean sprout fermented milk enriched in ?-aminobutyric acid on mild depression in a mouse model. J Dairy Sci. 2021;104(1):78-91. View abstract.
Yoto A, Murao S, Motoki M, Yokoyama Y, Horie N, Takeshima K, Masuda K, Kim M, Yokogoshi H. Oral intake of ?-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks. Amino Acids. 2012 Sep;43(3):1331-7. doi: 10.1007/s00726-011-1206-6. Epub 2011 Dec 28. View abstract.
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