Overview
The yohimbine in yohimbe can increase blood flow and nerve impulses to the penis or vagina. It can also help counteract the sexual side effects of certain medications used for depression.
People most commonly use yohimbe for sexual problems. It is also used to boost mood, for athletic performance, and other purposes, but there is no good scientific evidence to support these uses.
Uses & Effectiveness ?
We currently have no information for YOHIMBE overview.
Side Effects
Special Precautions and Warnings
Anxiety: Yohimbe might make anxiety worse in people with panic disorder. Don't use yohimbe if you have anxiety.
Prostate problems: Yohimbe might make the symptoms of BPH (benign prostatic hyperplasia) worse. Use yohimbe with caution if you have BPH.
Heart disease: Yohimbe can seriously harm the heart. Don't use it if you have heart disease.
High blood pressure: Yohimbe can increase blood pressure. Don't use it if you have high blood pressure.
Kidney disease: Yohimbe might slow or stop the flow of urine. Don't use yohimbe if you have kidney disease.
Liver disease: Liver disease might change the way the body processes yohimbe. Don't use yohimbe if you have liver disease.
Post-traumatic stress disorder (PTSD): Yohimbe might make PTSD symptoms worse.
Schizophrenia: The yohimbine in yohimbe might trigger psychosis in people with schizophrenia.
Surgery: Yohimbe might increase the risk for bleeding. People who take yohimbe should stop at least 2 weeks before surgery.
Interactions ?
Medications for depression (MAOIs) interacts with YOHIMBE
Yohimbe contains yohimbine. Yohimbine might affect the body in some of the same ways as some medications for depression called MAOIs. Taking yohimbe along with MAOIs might increase the effects and side effects of yohimbe and MAOIs.
Some common MAOIs include phenelzine (Nardil), selegiline (Zelapar), and tranylcypromine (Parnate).
Major Interaction
Do not take this combination
Medications for depression (Tricyclic antidepressants) interacts with YOHIMBE
Taking yohimbe along with these medications used for depression might cause shakiness and anxiety. Don't take yohimbe if you are taking these medications.
Medications for high blood pressure (Antihypertensive drugs) interacts with YOHIMBE
Yohimbe might increase blood pressure. Taking yohimbe might reduce the effects of blood pressure medications. Monitor your blood pressure closely.
Phenothiazines interacts with YOHIMBE
Yohimbe contains a chemical called yohimbine. Some medications called phenothiazines have some similar effects to yohimbine. Taking yohimbe along with phenothiazines might increase the risk for side effects.
Stimulant drugs interacts with YOHIMBE
Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. Yohimbe might also speed up the nervous system. Taking yohimbe along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with yohimbe.
Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with YOHIMBE
Some medications are changed and broken down by the liver. Yohimbe might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with YOHIMBE
Yohimbe might slow blood clotting. Taking yohimbe along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Medications that decrease break down of other medications by the liver (Cytochrome P450 2D6 (CYP2D6) inhibitors) interacts with YOHIMBE
Yohimbine is changed and broken down by the liver. Some drugs decrease how quickly the liver changes and breaks down yohimbe. This could change the effects and side effects of yohimbe.
Medications that decrease break down of other medications in the liver (Cytochrome P450 3A4 (CYP3A4) inhibitors) interacts with YOHIMBE
Yohimbine is changed and broken down by the liver. Some drugs decrease how quickly the liver changes and breaks down yohimbe. This could change the effects and side effects of yohimbe.
Moderate Interaction
Be cautious with this combination
Dosing
Abdel-Zaher, A. O., Ahmed, I. T., and El Koussi, A. D. The potential antidiabetic activity of some alpha-2 adrenoceptor antagonists. Pharmacol Res 2001;44(5):397-409. View abstract.
Abebe, W. An overview of herbal supplement utilization with particular emphasis on possible interactions with dental drugs and oral manifestations. J Dent.Hyg. 2003;77(1):37-46. View abstract.
Adeniyi, A. A., Brindley, G. S., Pryor, J. P., and Ralph, D. J. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl 2007;9(3):403-407. View abstract.
Adler, L. E., Hoffer, L., Nagamoto, H. T., Waldo, M. C., Kisley, M. A., and Giffith, J. M. Yohimbine impairs P50 auditory sensory gating in normal subjects. Neuropsychopharmacology 1994;10(4):249-257. View abstract.
Albus, M., Zahn, T. P., and Breier, A. Anxiogenic properties of yohimbine. I. Behavioral, physiological and biochemical measures. Eur.Arch.Psychiatry Clin.Neurosci. 1992;241(6):337-344. View abstract.
Albus, M., Zahn, T. P., and Breier, A. Anxiogenic properties of yohimbine. II. Influence of experimental set and setting. Eur Arch Psychiatry Clin Neurosci. 1992;241(6):345-351. View abstract.
Anden, N. E., Pauksens, K., and Svensson, K. Selective blockade of brain alpha 2-autoreceptors by yohimbine: effects on motor activity and on turnover of noradrenaline and dopamine. J Neural Transm. 1982;55(2):111-120. View abstract.
Andrejak, M., Ward, M., and Schmitt, H. Cardiovascular effects of yohimbine in anaesthetized dogs. Eur.J Pharmacol 10-28-1983;94(3-4):219-228. View abstract.
Anonymous. Yohimbine: time for resurrection? Lancet 11-22-1986;2(8517):1194-1195. View abstract.
Bagheri, H., Berlan, M., Montastruc, J. L., and Montastruc, P. Yohimbine and lacrimal secretion. Br J Clin Pharmacol. 1990;30(1):151-152. View abstract.
Bagheri, H., Bompart, G., Girolami, J. P., Montastruc, J. L., and Montastruc, P. Is yohimbine-induced increase in salivary secretion a kinin-dependent mechanism? Fundam.Clin Pharmacol 1992;6(1):17-20. View abstract.
Bagheri, H., Chale, J. J., Guyen, L. N., Tran, M. A., Berlan, M., and Montastruc, J. L. Evidence for activation of both adrenergic and cholinergic nervous pathways by yohimbine, an alpha 2-adrenoceptor antagonist. Fundam.Clin Pharmacol 1995;9(3):248-254. View abstract.
Bagheri, H., Schmitt, L., Berlan, M., and Montastruc, J. L. A comparative study of the effects of yohimbine and anetholtrithione on salivary secretion in depressed patients treated with psychotropic drugs. Eur.J Clin Pharmacol. 1997;52(5):339-342. View abstract.
Bagheri, H., Schmitt, L., Berlan, M., and Montastruc, J. L. Effect of 3 weeks treatment with yohimbine on salivary secretion in healthy volunteers and in depressed patients treated with tricyclic antidepressants. Br J Clin Pharmacol 1992;34(6):555-558. View abstract.
Balon R. The effects of anitdepressants on human sexuality: Diagnosis and management update 1999. Primary Psychology 1999;6(11):40-54.
Balon, R. Fluoxetine-induced sexual dysfunction and yohimbine. J Clin Psychiatry 1993;54(4):161-162. View abstract.
Berlan, M., Galitzky, J., Riviere, D., Foureau, M., Tran, M. A., Flores, R., Louvet, J. P., Houin, G., and Lafontan, M. Plasma catecholamine levels and lipid mobilization induced by yohimbine in obese and non-obese women. Int.J Obes. 1991;15(5):305-315. View abstract.
Berlin, I., Crespo-Laumonnier, B., Cournot, A., Landault, C., Aubin, F., Legrand, J. C., and Puech, A. J. The alpha 2-adrenergic receptor antagonist yohimbine inhibits epinephrine-induced platelet aggregation in healthy subjects. Clin Pharmacol.Ther. 1991;49(4):362-369. View abstract.
Berlin, I., Crespo-Laumonnier, B., Turpin, G., and Puech, A. J. The alpha-2 adrenoceptor antagonist yohimbine does not facilitate weight loss but blocks adrenaline induced platelet aggregation in obese subjects. Therapie 1989;44(4):301. View abstract.
Berlin, I., Stalla-Bourdillon, A., Thuillier, Y., Turpin, G., and Puech, A. J. [Lack of efficacy of yohimbine in the treatment of obesity]. J Pharmacol 1986;17(3):343-347. View abstract.
Betz, J. M., White, K. D., and der Marderosian, A. H. Gas chromatographic determination of yohimbine in commercial yohimbe products. J AOAC Int 1995;78(5):1189-1194. View abstract.
Biaggioni, I., Robertson, R. M., and Robertson, D. Manipulation of norepinephrine metabolism with yohimbine in the treatment of autonomic failure. J Clin Pharmacol. 1994;34(5):418-423. View abstract.
Bierer, L. M., Aisen, P. S., Davidson, M., Ryan, T. M., Stern, R. G., Schmeidler, J., and Davis, K. L. A pilot study of oral physostigmine plus yohimbine in patients with Alzheimer disease. Alzheimer Dis.Assoc.Disord. 1993;7(2):98-104. View abstract.
Bloomer, R. J., Canale, R. E., Blankenship, M. M., Hammond, K. G., Fisher-Wellman, K. H., and Schilling, B. K. Effect of the dietary supplement Meltdown on catecholamine secretion, markers of lipolysis, and metabolic rate in men and women: a randomized, placebo controlled, cross-over study. Lipids Health Dis 2009;8:32. View abstract.
Bolme, P., Corrodi, H., Fuxe, K., Hokfelt, T., Lidbrink, P., and Goldstein, M. Possible involvement of central adrenaline neurons in vasomotor and respiratory control. Studies with clonidine and its interactions with piperoxane and yohimbine. Eur J Pharmacol 1974;28(1):89-94. View abstract.
Boon, N. A., Elliott, J. M., Grahame-Smith, D. G., John-Green, T., and Stump, K. A comparison of alpha 2-adrenoreceptor binding characteristics of intact human platelets identified by [3H]-yohimbine and [3H]- dihydroergocryptine. J Auton.Pharmacol 1983;3(2):89-95. View abstract.
Bourin, M., Malinge, M., and Guitton, B. Provocative agents in panic disorder. Therapie 1995;50(4):301-306. View abstract.
Bowes, M. P., Peters, R. H., Kernan, W. J., Jr., and Hopper, D. L. Effects of yohimbine and idazoxan on motor behaviors in male rats. Pharmacol.Biochem.Behav. 1992;41(4):707-713. View abstract.
Braddock, L. E., Cowen, P. J., Elliott, J. M., Fraser, S., and Stump, K. Changes in the binding to platelets of [3H]imipramine and [3H]yohimbine in normal subjects taking amitriptyline. Neuropharmacology 1984;23(2B):285-286. View abstract.
Braddock, L., Cowen, P. J., Elliott, J. M., Fraser, S., and Stump, K. Binding of yohimbine and imipramine to platelets in depressive illness. Psychol.Med 1986;16(4):765-773. View abstract.
Bremner, J. D., Innis, R. B., Ng, C. K., Staib, L. H., Salomon, R. M., Bronen, R. A., Duncan, J., Southwick, S. M., Krystal, J. H., Rich, D., Zubal, G., Dey, H., Soufer, R., and Charney, D. S. Positron emission tomography measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder. Arch.Gen.Psychiatry 1997;54(3):246-254. View abstract.
Brodde, O. E., Anlauf, M., Arroyo, J., Wagner, R., Weber, F., and Buck, K. D. Hypersensitivity of adrenergic receptors and blood-pressure response to oral yohimbine in orthostatic hypotension. N.Engl.J Med 4-28-1983;308(17):1033-1034. View abstract.
Cameron, O. G., Zubieta, J. K., Grunhaus, L., and Minoshima, S. Effects of yohimbine on cerebral blood flow, symptoms, and physiological functions in humans. Psychosom.Med 2000;62(4):549-559. View abstract.
Charney, D. S., Heninger, G. R., and Redmond, D. E., Jr. Yohimbine induced anxiety and increased noradrenergic function in humans: effects of diazepam and clonidine. Life Sci. 7-4-1983;33(1):19-29. View abstract.
Charney, D. S., Heninger, G. R., and Sternberg, D. E. Assessment of alpha 2 adrenergic autoreceptor function in humans: effects of oral yohimbine. Life Sci 6-7-1982;30(23):2033-2041. View abstract.
Charney, D. S., Price, L. H., and Heninger, G. R. Desipramine-yohimbine combination treatment of refractory depression. Implications for the beta-adrenergic receptor hypothesis of antidepressant action. Arch.Gen.Psychiatry 1986;43(12):1155-1161. View abstract.
Chatelut, E., Rispail, Y., Berlan, M., and Montastruc, J. L. Yohimbine increases human salivary secretion. Br.J Clin Pharmacol. 1989;28(3):366-368. View abstract.
Cimolai, N. and Cimolai, T. Yohimbine use for physical enhancement and its potential toxicity. J Diet.Suppl 2011;8(4):346-354. View abstract.
Dwoskin, L. P., Neal, B. S., and Sparber, S. B. Evidence for antiserotonergic properties of yohimbine. Pharmacol Biochem.Behav. 1988;31(2):321-326. View abstract.
Ernst, E., Posadzki, P., and Lee, M. S. Complementary and alternative medicine (CAM) for sexual dysfunction and erectile dysfunction in older men and women: an overview of systematic reviews. Maturitas 2011;70(1):37-41. View abstract.
Fleurence, R., Williamson, R., Jing, Y., Kim, E., Tran, Q. V., Pikalov, A. S., and Thase, M. E. A systematic review of augmentation strategies for patients with major depressive disorder. Psychopharmacol.Bull. 2009;42(3):57-90. View abstract.
Friesen, K., Palatnick, W., and Tenenbein, M. Benign course after massive ingestion of yohimbine. J Emerg.Med 1993;11(3):287-288. View abstract.
Galitzky, J., Taouis, M., Berlan, M., Riviere, D., Garrigues, M., and Lafontan, M. Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers. Eur.J Clin Invest 1988;18(6):587-594. View abstract.
Giampreti, A., Lonati, D., Locatelli, C., Rocchi, L., and Campailla, M. T. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol.(Phila) 2009;47(8):827-829. View abstract.
Goldberg, M. R. and Robertson, D. Yohimbine: a pharmacological probe for study of the alpha 2- adrenoreceptor. Pharmacol Rev. 1983;35(3):143-180. View abstract.
Grossman, E., Rea, R. F., Hoffman, A., and Goldstein, D. S. Yohimbine increases sympathetic nerve activity and norepinephrine spillover in normal volunteers. Am J Physiol 1991;260(1 Pt 2):R142-R147. View abstract.
Gurguis, G. N., Vitton, B. J., and Uhde, T. W. Behavioral, sympathetic and adrenocortical responses to yohimbine in panic disorder patients and normal controls. Psychiatry Res. 6-16-1997;71(1):27-39. View abstract.
Guthrie, S. K., Hariharan, M., and Grunhaus, L. J. Yohimbine bioavailability in humans. Eur.J Clin Pharmacol 1990;39(4):409-411. View abstract.
Gyllenhaal, C., Merritt, S. L., Peterson, S. D., Block, K. I., and Gochenour, T. Efficacy and safety of herbal stimulants and sedatives in sleep disorders. Sleep Med Rev. 2000;4(3):229-251. View abstract.
Ho, A. K., Hoffman, D. B., Gershon, S., and Loh, H. H. Distribution and metabolism of tritiated yohimbine in mice. Arch.Int.Pharmacodyn.Ther 1971;194(2):304-315. View abstract.
Ho, C. C. and Tan, H. M. Rise of herbal and traditional medicine in erectile dysfunction management. Curr Urol.Rep. 2011;12(6):470-478. View abstract.
Holmes, A. and Quirk, G. J. Pharmacological facilitation of fear extinction and the search for adjunct treatments for anxiety disorders--the case of yohimbine. Trends Pharmacol Sci 2010;31(1):2-7. View abstract.
Jordan, J., Shannon, J. R., Biaggioni, I., Norman, R., Black, B. K., and Robertson, D. Contrasting actions of pressor agents in severe autonomic failure. Am J Med. 1998;105(2):116-124. View abstract.
Kennedy, S. H., Gnam, W., Ralevski, E., and Brown, G. M. Melatonin responses to clonidine and yohimbine challenges. J Psychiatry Neurosci. 1995;20(4):297-304. View abstract.
Kenney, W. L., Zappe, D. H., Tankersley, C. G., and Derr, J. A. Effect of systemic yohimbine on the control of skin blood flow during local heating and dynamic exercise. Am J Physiol 1994;266(2 Pt 2):H371-H376. View abstract.
Knoll, L. D., Benson, R. C., Jr., Bilhartz, D. L., Minich, P. J., and Furlow, W. L. A randomized crossover study using yohimbine and isoxsuprine versus pentoxifylline in the management of vasculogenic impotence. J Urol. 1996;155(1):144-146. View abstract.
Landis, E. and Shore, E. Yohimbine-induced bronchospasm. Chest 1989;96(6):1424. View abstract.
Le Corre, P., Dollo, G., Chevanne, F., and Le Verge, R. Biopharmaceutics and metabolism of yohimbine in humans. Eur J Pharm Sci 1999;9(1):79-84. View abstract.
Lebret, T., Herve, J. M., Gorny, P., Worcel, M., and Botto, H. Efficacy and safety of a novel combination of L-arginine glutamate and yohimbine hydrochloride: a new oral therapy for erectile dysfunction. Eur Urol. 2002;41(6):608-613. View abstract.
Mann, K., Klingler, T., Noe, S., Roschke, J., Muller, S., and Benkert, O. Effects of yohimbine on sexual experiences and nocturnal penile tumescence and rigidity in erectile dysfunction. Arch.Sex Behav. 1996;25(1):1-16. View abstract.
Mazo R and Sonda LP. A prospective double blind trial of yohimbine for erectile impotence [abstract]. 79th Annual Meeting of the American Urological Association, Baltimore 1984;234/A.
Melman A. The effects of yohimbine upon sexual function: a double-blind study [abstract]. 79th Annual Meeting of the American Urological Association, Baltimore :302/A.
Meyerbroeker, K., Powers, M. B., van, Stegeren A., and Emmelkamp, P. M. Does yohimbine hydrochloride facilitate fear extinction in virtual reality treatment of fear of flying? A randomized placebo-controlled trial. Psychother.Psychosom. 2012;81(1):29-37. View abstract.
Miller, W. W., Jr. Afrodex in the treatment of male impotence: a double-blind cross-over study. Curr.Ther.Res.Clin Exp. 1968;10(7):354-359. View abstract.
Montague, D. K., Barada, J. H., Belker, A. M., Levine, L. A., Nadig, P. W., Roehrborn, C. G., Sharlip, I. D., and Bennett, A. H. Clinical guidelines panel on erectile dysfunction: summary report on the treatment of organic erectile dysfunction. The American Urological Association. J Urol. 1996;156(6):2007-2011. View abstract.
Montastruc, J. L., Puech, A. J., Clanet, M., Guiraud-Chaumeil, B., and Rascol, A. [Yohimbine in treatment of Parkinson's disease. Preliminary results (author's transl)]. Nouv.Presse Med 4-11-1981;10(16):1331-1332. View abstract.
Montastruc, P., Berlan, M., and Montastruc, J. L. Effects of yohimbine on submaxillary salivation in dogs. Br J Pharmacol 1989;98(1):101-104. View abstract.
Morales, A. Yohimbine in erectile dysfunction: the facts. Int.J.Impot.Res. 2000;12 Suppl 1:S70-S74. View abstract.
Morales, A., Condra, M., Owen, J. A., Surridge, D. H., Fenemore, J., and Harris, C. Is yohimbine effective in the treatment of organic impotence? Results of a controlled trial. J Urol. 1987;137(6):1168-1172. View abstract.
Morales, A., Surridge, D. H., and Marshall, P. G. Yohimbine for treatment of impotence in diabetes. N.Engl.J Med 11-12-1981;305(20):1221. View abstract.
Morales, A., Surridge, D. H., Marshall, P. G., and Fenemore, J. Nonhormonal pharmacological treatment of organic impotence. J Urol. 1982;128(1):45-47. View abstract.
Morgan, C. A., III, Grillon, C., Southwick, S. M., Nagy, L. M., Davis, M., Krystal, J. H., and Charney, D. S. Yohimbine facilitated acoustic startle in combat veterans with post- traumatic stress disorder. Psychopharmacology (Berl) 1995;117(4):466-471. View abstract.
Morgan, C. A., III, Southwick, S. M., Grillon, C., Davis, M., Krystal, J. H., and Charney, D. S. Yohimbine-facilitated acoustic startle reflex in humans. Psychopharmacology (Berl) 1993;110(3):342-346. View abstract.
Mosqueda-Garcia, R., Fernandez-Violante, R., Tank, J., Snell, M., Cunningham, G., and Furlan, R. Yohimbine in neurally mediated syncope. Pathophysiological implications. J Clin Invest 11-15-1998;102(10):1824-1830. View abstract.
Motulsky, H. J., Shattil, S. J., and Insel, P. A. Characterization of alpha 2-adrenergic receptors on human platelets using [ View abstract.
Murburg, M. M., Villacres, E. C., Ko, G. N., and Veith, R. C. Effects of yohimbine on human sympathetic nervous system function. J Clin Endocrinol.Metab 1991;73(4):861-865. View abstract.
Musso, N. R., Vergassola, C., Pende, A., and Lotti, G. Yohimbine effects on blood pressure and plasma catecholamines in human hypertension. Am J Hypertens. 1995;8(6):565-571. View abstract.
Mustonen, P., Savola, J., and Lassila, R. Atipamezole, an imidazoline-type alpha(2)-adrenoceptor inhibitor, binds to human platelets and inhibits their adrenaline-induced aggregation more effectively than yohimbine. Thromb.Res 8-1-2000;99(3):231-237. View abstract.
Myers, A. and Barrueto, F., Jr. Refractory priapism associated with ingestion of yohimbe extract. J Med Toxicol. 2009;5(4):223-225. View abstract.
Okamoto, L. E., Shibao, C., Gamboa, A., Choi, L., Diedrich, A., Raj, S. R., Black, B. K., Robertson, D., and Biaggioni, I. Synergistic effect of norepinephrine transporter blockade and alpha-2 antagonism on blood pressure in autonomic failure. Hypertension 2012;59(3):650-656. View abstract.
Ostojic, S. M. Yohimbine: the effects on body composition and exercise performance in soccer players. Res Sports Med 2006;14(4):289-299. View abstract.
Papeschi, R. and Theiss, P. The effect of yohimbine on the turnover of brain catecholamines and serotonin. Eur J Pharmacol 1975;33(1):1-12. View abstract.
Piletz, J. E., Segraves, K. B., Feng, Y. Z., Maguire, E., Dunger, B., and Halaris, A. Plasma MHPG response to yohimbine treatment in women with hypoactive sexual desire. J Sex Marital Ther. 1998;24(1):43-54. View abstract.
Powers, M. B., Smits, J. A., Otto, M. W., Sanders, C., and Emmelkamp, P. M. Facilitation of fear extinction in phobic participants with a novel cognitive enhancer: a randomized placebo controlled trial of yohimbine augmentation. J Anxiety.Disord. 2009;23(3):350-356. View abstract.
Rasmusson, A. M., Hauger, R. L., Morgan, C. A., Bremner, J. D., Charney, D. S., and Southwick, S. M. Low baseline and yohimbine-stimulated plasma neuropeptide Y (NPY) levels in combat-related PTSD. Biol.Psychiatry 3-15-2000;47(6):526-539. View abstract.
Reid, K., Surridge, D. H., Morales, A., Condra, M., Harris, C., Owen, J., and Fenemore, J. Double-blind trial of yohimbine in treatment of psychogenic impotence. Lancet 8-22-1987;2(8556):421-423. View abstract.
Riley AJ, Goodman R, Kellett JM, and et al. Double blind trial of yohimbine hydrochloride in the treatment of erection inadequacy. Sexual Marital Ther 1989;4(1):17-26.
Rowland, D. L., Kallan, K., and Slob, A. K. Yohimbine, erectile capacity, and sexual response in men. Arch Sex Behav 1997;26(1):49-62. View abstract.
Shibao, C., Okamoto, L. E., Gamboa, A., Yu, C., Diedrich, A., Raj, S. R., Robertson, D., and Biaggioni, I. Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure. Hypertension 2010;56(5):847-851. View abstract.
Siddiqui, M. A., More-O'Ferrall, D., Hammod, R. S., Baime, R. V., and Staddon, A. P. Agranulocytosis associated with yohimbine use. Arch.Intern.Med 6-10-1996;156(11):1235-1237. View abstract.
Soeter, M. and Kindt, M. Stimulation of the noradrenergic system during memory formation impairs extinction learning but not the disruption of reconsolidation. Neuropsychopharmacology 2012;37(5):1204-1215. View abstract.
Sonda, L. P., Mazo, R., and Chancellor, M. B. The role of yohimbine for the treatment of erectile impotence. J Sex Marital Ther. 1990;16(1):15-21. View abstract.
Southwick, S. M., Krystal, J. H., Bremner, J. D., Morgan, C. A., III, Nicolaou, A. L., Nagy, L. M., Johnson, D. R., Heninger, G. R., and Charney, D. S. Noradrenergic and serotonergic function in posttraumatic stress disorder. Arch.Gen.Psychiatry 1997;54(8):749-758. View abstract.
Sturgill, M. G., Grasing, K. W., Rosen, R. C., Thomas, T. J., Kulkarni, G. D., Trout, J. R., Maines, M., and Seibold, J. R. Yohimbine elimination in normal volunteers is characterized by both one- and two-compartment behavior. J Cardiovasc.Pharmacol. 1997;29(6):697-703. View abstract.
Susset, J. G., Tessier, C. D., Wincze, J., Bansal, S., Malhotra, C., and Schwacha, M. G. Effect of yohimbine hydrochloride on erectile impotence: a double-blind study. J Urol. 1989;141(6):1360-1363. View abstract.
Swann, A. C. Mechanisms of impulsivity in bipolar disorder and related illness. Epidemiol.Psichiatr.Soc. 2010;19(2):120-130. View abstract.
Swann, A. C., Birnbaum, D., Jagar, A. A., Dougherty, D. M., and Moeller, F. G. Acute yohimbine increases laboratory-measured impulsivity in normal subjects. Biol.Psychiatry 5-15-2005;57(10):1209-1211. View abstract.
Vogt, H. J., Brandl, P., Kockott, G., Schmitz, J. R., Wiegand, M. H., Schadrack, J., and Gierend, M. Double-blind, placebo-controlled safety and efficacy trial with yohimbine hydrochloride in the treatment of nonorganic erectile dysfunction. Int J Impot.Res 1997;9(3):155-161. View abstract.
Ashton AK. Yohimbine in the treatment of male erectile dysfunction. Am J Psychiatr 1994;151:1397. View abstract.
Balon R. Fluoxetine-induced sexual dysfunction and yohimbine. J Clin Psychiatry 1993;54:161-2. View abstract.
Balon R. The effects of anitdepressants on human sexuality: diagnosis and management update 1999. Primary Psychiatry 1999;6:40-54.
Barnes ME, Cowan CR, Boag LE, et al. Effects of Acute Yohimbine Hydrochloride Supplementation on Repeated Supramaximal Sprint Performance. Int J Environ Res Public Health 2022;19(3):1316. View abstract.
Bharucha AE, Skaar T, Andrews CN, et al Relationship of cytochrome P450 pharmacogenetics to the effects of yohimbine on gastrointestinal transit and catecholamines in healthy subjects. Neurogastroenterol Motil. 2008;20(8):891-9. View abstract.
Bucci LR. Selected herbals and human exercise performance. Am J Clin Nutr 2000;72:624S-36S.. View abstract.
Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
Cappiello A, McDougle CJ, Malison RT, et al. Yohimbine augmentation of Fluvoxamine in refactory depression: a single blind study. Biol Psychiatry 1995;38:765-7. View abstract.
Carey MP, Johnson BT. Effectiveness of yohimbine in the treatment of erectile disorder: four meta-analytic integrations. Arch Sex Behav 1996;25:341-60. View abstract.
Chevallier A. The Encyclopedia of Medicinal Plants. London, UK: Dorling Kindersley, Ltd., 1996.
Cohen PA, Wang YH, Maller G, DeSouza R, Khan IA. Pharmaceutical quantities of yohimbine found in dietary supplements in the USA. Drug Test Anal. 2015 Sep 22. View abstract.
EFSA Panel on Food Additives and Nutrient Sources Added to Food (ANS). Scientific Opinion on the evaluation of the safety in use of Yohimbe (Pausinystalia yohimbe (K. Schum.) Pierre ex Beille). EFSA J. 2013;11(7):3302.
Ernst E, Pittler MH. Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials. J Urol 1998;159:433-6.. View abstract.
Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999.
Harvey KV, Balon R. Clinical implications of antidepressant drug effects on sexual function. Ann Clin Psychiatry 1995;7:189-201. View abstract.
Herman AM, Critchley HD, Duka T. The impact of yohimbine-induced arousal on facets of behavioural impulsivity. Psychopharmacology (Berl). 2019;236(6):1783-1795. View abstract.
Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9. View abstract.
Hostettmann K, Marston A, Ndjoko K, Wolfender J-L. The Potential of African Plants as a Source of Drugs. Curr Org Chem 2000;4:973-1010.
Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22. View abstract.
Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. View abstract.
Kuehl LK, Deuter CE, Hellmann-Regen J, Kaczmarczyk M, Otte C, Wingenfeld K. Enhanced noradrenergic activity by yohimbine and differential fear conditioning in patients with major depression with and without adverse childhood experiences. Prog Neuropsychopharmacol Biol Psychiatry. 2020;96:109751. View abstract.
Kunellius P, Hakkinen J, Lukkarinen O. Is high-dose yohimbine hydrochloride effective in the treatment of mixed-type impotence? A prospective, randomized, controlled, double-blind crossover study. Urol 1997;49:441-4. View abstract.
Le Corre P, Parmer RJ, Kailasam MT, et al. Human sympathetic activation by alpha2-adrenergic blockade with yohimbine: Bimodal, epistatic influence of cytochrome P450-mediated drug metabolism. Clin Pharmacol Ther. 2004;76(2):139-53. View abstract.
Metz S, Waiblinger-Grigull T, Schulreich S, et al. Effects of hydrocortisone and yohimbine on decision-making under risk. Psychoneuroendocrinology. 2020;114:104589. View abstract.
Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7. View abstract.
Montorsi F, Strambi LF, Guazzoni G, et al. Effect of yohimbine-trazodone on psychogenic impotence: a randomized, double-blind, placebo-controlled study. Urology 1994;44:732-6. View abstract.
Mueller-Schoell A, Michelet R, Weinelt F, Kloft C, Mikus G. CYP2D6 phenotype explains reported yohimbine concentrations in four severe acute intoxications. Arch Toxicol. 2021. View abstract.
Owen JA, Nakatsu SL, Fenemore J, et al. The pharmacokinetics of yohimbine in man. Eur J Clin Pharmacol 1987;3:877-82. View abstract.
PremesisRx. Pharmacist's Letter / Prescriber's Letter 1999:15(12);151206.
Ruck B, Shih RD, Marcus SM. Hypertensive crisis from herbal treatment of impotence. Am J Emerg Med. 1999;17:317-318.
Sanacora G, Berman RM, Cappiello A, et al. Addition of the alpha2-antagonist yohimbine to fluoxetine: effects on rate of antidepressant response. Neuropsychopharmacology. 2004;29(6):1166-71. View abstract.
Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5. View abstract.
Scheinin H, Virtanen R. Effects of yohimbine and idazoxan on monoamine metabolites in rat cerebrospinal fluid. Life Sci. 1986 Oct 20;39(16):1439-46. View abstract.
Schmauss M, Laakmann G, Dieterle D. Effects of alpha 2-receptor blockade in addition to tricyclic antidepressants in therapy-resistant depression. J Clin Psychopharmacol. 1988;8(2):108-11. View abstract.
Schneider DL, Barrett-Connor EL, Morton DJ. Thyroid hormone use and bone mineral density in elderly men. Arch Intern Med 1995;155:2005-7. View abstract.
Southwick SM, Morgan CA III, Charney DS, High JR. Yohimbine use in a natural setting: effects on post-traumatic stress disorder. Biol Psychiatr 1999;46:442-4. View abstract.
Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. View abstract.
VandenBrink, B. M., Foti, R. S., Rock, D. A., Wienkers, L. C., and Wahlstrom, J. L. Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. Drug Metab Dispos. 2012;40(1):47-53. View abstract.
Varnell MA. Enhanced herb may help female sexual dysfunction. Reuters Health 2000;Jun 27. www.reutershealth.com/frame/eline.html (Accessed 28 June 2000).
Wagner G, Saenz de Tejada IS. Update on male erectile dysfunction. BMJ 1998;316:678-82. View abstract.
Wibowo DNSA, Soebadi DM, Soebadi MA. Yohimbine as a treatment for erectile dysfunction: A systematic review and meta-analysis. Turk J Urol 2021;47(6):482-488. View abstract.
Witt DK. Yohimbine for erectile dysfuntion. J Fam Pract 1998;46:282-3. View abstract.
Wylie KR. Yohimbine and sinusitis. Br J Psychiatry. 1996;169(3):384-5. View abstract.
Yan J and Wang W. A comparative effects of Sildenafil (Viagra) and yohimbine for the treatment of erectile dysfunction. Chinese J or Andrology. 2000;14(2):103-5.
Zhu L, Han X, Zhu J, Du L, Liu L, Gong W. Severe acute intoxication with yohimbine: Four simultaneous poisoning cases. Forensic Sci Int. 2021;320:110705. View abstract.
Select a condition to view a list of vitamins
You Might Also Like
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.